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 Byers,Margaret R. Ph.D.
Research Professor, Emeritus
RR-440 Health Sciences
RR-410 Health Sciences
FAX: 206 685-3079
Vmail: 206 685-1868
byersm@u.washington.edu
My research focuses on the neurobiology of peripheral nerve fibers that cause pain,
including their functions in normal tissues, interactions with inflammation, contributions to wound healing,
and reactions to anesthetics and other clinical treatments. We have worked with many animal models,
including various models of tooth injury or trigeminal nerve pathology, mutant mice with altered
neurotrophin growth factor mechanisms, and human teeth. In addition we have interests in the
development of teeth and their innervation, as well as in immune capabilities of teeth and dental
innervation. I have recently graduated to the emeritus research faculty, but continue to maintain a fully
active laboratory in the Anesthesiology Department. I also have strong collaborations with other faculty
and students in the Anesthesiology and Pharmacology Departments and the Dental School, as well as grant
funding from NIH and independent foundations, which continue to keep our research program active and fun.
Byers, M.R. and Narhi, MVO: Dental Injury Models: Experimental tools for understanding
neuroinflammatory interactions and polymodal nociceptor functions. Crit Rev Oral Biol and Med.,10:4-39, 1999.
Woodnutt, D. A., Wager-Miller, J., O'Neill, P.C., Bothwell, M., and Byers, M.R. Neurotrophin receptors and
NGF are differentially expressed in adjacent non neuronal cells of normal and injured tooth pulp. Cell Tissue Res 299:225-236, 2000.
Byers, M.R., Chudler, E.H., and Iadarola, M.J.: Chronic tooth pulp inflammation causes transient and
persistent expression of Fos in dynorphin-rich regions of rat brain stem. Brain Research 861:191- 207, 2000.
Byers MR, Bonica JJ: Peripheral Pain Mechanisms and Nociceptor Plasticity. Chap 3, in "Bonica's
Management of Pain" 3rd Edition, Williams & Wilkins, New York pp26-72, 2001.
Byers MR and Narhi MVO: Nerve Supply of Dentin-Pulp Complex and Responses to Injury. In: Seltzer &
Bender's Dental Pulp, Eds. KM Hargreaves, H Goodis, Quintessence, pp151-180, 2002.
Byers MR, Suzuki H, Maeda T: Dental neuroplasticity, neuro-pulpal interactions and nerve regeneration.
Microsc Res Techn, 60:503-515, 2003.
Byers MR, Yoon Lin KJ. Patterns of Fluorogold entry into rat molar enamel, dentin and pulp. J Dent Res
82:312-317, 2003.
Westenbroek RE, Anderson NL, Byers MR. Altered expression of L-type calcium channels in nerve fibers,
Schwann cells, odontoblasts & fibroblasts of the tooth pulp following tooth injury. J Neurosci Res, 75:371-383, 2004.
Byers, M.R., Maeda, T., Brown, A.M and Westenbroek, R.E. GFAP immunoreactivity and transcription in
trigeminal and dental tissues of rats and transgenic GFP/GFAP mice. Microsc. Res. Techn. 65:295-307, 2004.
Kvinnsland IH, Luukko K, Fristad I, Kettunen P, Jackson DL, Fjeld K, von Bartheld CS, Byers MR. Glial cell
line-derived neurotrophic factgor (GDNF) from adult rat tooth subserves distinct population of large-sized
trigeminal neurons. Eur J Neurosci, 19:2089-2098, 2004.
Chudler EH, Byers MR. Behavioral responses following tooth injury in rats. Arch Oral Biol. 50:333-340, 2005.
Veerayutthwilai O, Luis NA, Crumpton RM, MacDonald GH, Byers MR. Peripherin- and CGRP-immunoreactive
nerve fibers in rat molars have different locations and developmental timing. Arch Oral Biol., epub May 2006 51:748-760, 2006
Veerayutthwilai O, Byers MR, Pham T-T, Darveau RP, Dale BA. Differential regulation of immune responses
by odontoblasts. Oral Microb Immuno, 2007; 22:5-13.
Neuhaus SJ, Byers MR . Endothelin receptors in developing rat teeth. Arch. Oral Biol 2007; 52(7):655-62.
Byers MR. Tooth Pain. In The Senses, A Comprehensive Reference, (edited by R.R.Hoy et al.) Vol. 3
"Pain" (edited Allan I. Basbaum) New York: Elsevier, in press, 2007.
Fristad I, Bletsa A, Byers MR. Inflammatory nerve responses in the dental pulp. Endodon. Topics, in press.
Byers MR, Henry MA, Narhi MVO. Dental Innervation and Its Responses to tooth Injury. In: Hargreaves KM
, Goodis HE, "Seltzer and Bender's Dental Pulp". Quintessence/Chicago, 2nd Edition, in press.
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