Selected publications

Cho, U., and Xu, W. Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature (Article), in press.

Sampietro, S., Dahlberg, C.L., Cho , U.S. , Hinds, T.R., Kimelman, D., and Xu, W. (2006). Crystal Structure of a b -catenin/BCL9/Tcf4 Complex. Molecular Cell , 24, 293-300.

Kimelman, D., and Xu, W. (2006). The b -catenin destruction complex: insights and questions from a structural perspective (review). Oncogene , 25, 7482-7491.

Liu, J., Xing, Y., Hinds, T.R., Zheng. J., Xu, W. (2006). The third 20 amino acid repeat is the tightest binding site of APC for b -catenin. Journal of Molecular Biology. 360, 133-144.

Cho, U., Bader, M., Amaya, M. F., Delay, M. E. , Klevit, K., Miller, S., and Xu, W. (2006). Metal Bridges between the PhoQ Sensor Domain and the Membrane Regulate Transmembrane Signaling. Journal of Molecular Biology. 356, 1193-1206. (highlighted by Science in the Editor's Choice section).

Zhu, Y., Huang, W., Lee, S.K. and Xu, W. (2005). Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis. EMBO Reports , 6, 681-687.

Bader, M. W., Sanowar, S. , Daley, M. E. , Schneider, A. R., Cho, U. , Xu, W., Klevit, R. E., Le Moual, H. , Miller, S. I. (2005). Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase. Cell , 122, 461-472.

Xing, Y., Clements, W.K., Le Trong, I. , Hinds, T.R., Stenkamp, R., Kimelman, D. and Xu, W. (2004). Crystal structure of a b -catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Molecular Cell . 15, 523-533. (cover story)

Xing, Y., Liu, D., Zhang, R., Joachimiak, A., Songyang, Z. and Xu, W. (2004). Structural basis of membrane targeting by the phox homology domain of cytokine-independent survival kinase (CISK-PX). Journal of Biological Chemistry . 279, 30662-30669.

Xing, Y., Clements, W., Kimelman, D. and Xu, W. (2003). Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the beta-catenin destruction complex. Genes and Development , 17, 2753-2764. (cover story)

Graham, T., Clements, W., Kimelman, D., Xu, W. (2002). Crystal structure of the beta-catenin/ICAT complex reveals a inhibitory mechanism of Wnt signaling pathway. Molecular Cell , 10, 563-571.

Graham, T., Ferkey, D. M., Mao, F., Kimelman, D., Xu, W. (2001). Structure basis of b -catenin/Tcf-4 interactions. Nature Structure Biology , 8, 1048-1052.

Graham, T., Weaver, C., Mao, F., Kimelman, D., Xu, W. (2000). Crystal structure of a b -catenin/Tcf complex. Cell , 103, 885-896.

Xu, W., Doshi, A., Lei, M., Eck, M. J., and Harrison, S. C. (1999). Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Molecular Cell 3, 629-638.

Xu, W., Harrison, S. C., and Eck, M. J. (1997). Three-dimensional structure of the tyrosine kinase c-Src. Nature 385, 595-602.

Xu, W., Rould, M. A., Jun, S., Desplan, C., and Pabo, C. O. (1995). Crystal structure of a paired domain-DNA complex at 2.5Å resolution reveals structural basis for Pax developmental mutations. Cell 80, 639-650.